A model of thermotherapy treatment for bladder cancer

Christoph  Sadée; Eugene  Kashdan

doi:10.3934/mbe.2016037

Article Contents

2016, Volume 13, Issue 6: 1169-1183. Doi: 10.3934/mbe.2016037

This issue Previous Article Modelling random antibody adsorption and immunoassay activity Next Article Limiting the development of anti-cancer drug resistance in a spatial model of micrometastases

A model of thermotherapy treatment for bladder cancer

Christoph Sadée^1, and
Eugene Kashdan^1,

1.
School of Mathematics and Statistics, University College Dublin, Belfield, Dublin 4

Received: November 30, 2015

Revised: February 29, 2016

Published: July 2016

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Abstract

In this work, we investigate chemo- thermotherapy, a recently clinically-approved post-surgery treatment of non muscle invasive urothelial bladder carcinoma. We developed a mathematical model and numerically simulated the physical processes related to this treatment. The model is based on the conductive Maxwell's equations used to simulate the therapy administration and Convection-Diffusion equation for incompressible fluid to study heat propagation through the bladder tissue. The model parameters correspond to the data provided by the thermotherapy device manufacturer. We base our computational domain on a CT image of a human bladder. Our numerical simulations can be applied to further research on the effects of chemo- thermotherapy on bladder and surrounding tissues and for treatment personalization in order to maximize the effect of the therapy while avoiding burning of the bladder.

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Mathematics Subject Classification: Primary: 35Q92; Secondary: 92C35, 92C55.

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