# American Institute of Mathematical Sciences

June  2017, 14(3): 805-820. doi: 10.3934/mbe.2017044

## A note on the global properties of an age-structured viral dynamic model with multiple target cell populations

 1 School of Mathematics and Statistics, Henan University, Kaifeng 475001, Henan, China 2 Centre for Disease Modelling, York University, Toronto, Ontario, M3J 1P3, Canada 3 Department of Mathematics and Statistics, Oakland University, Rochester, MI 48309, USA

Received  January 25, 2016 Accepted  October 30, 2016 Published  December 2016

Fund Project: This work was finished when S. Wang visited York University. Wang is supported by NSFC (No.11326200), Foundation of He’nan Educational Committee (No.15A110015, No.15A110018), and The Grant of China Scholarship Council (No.201408410018). L. Rong is partially supported by the NSF grant DMS-1349939.

Some viruses can infect different classes of cells. The age of infection can affect the dynamics of infected cells and viral production. Here we develop a viral dynamic model with the age of infection and multiple target cell populations. Using the methods of semigroup and Lyapunov function, we study the global asymptotic property of the steady states of the model. The results show that when the basic reproductive number falls below 1, the infection is predicted to die out. When the basic reproductive number exceeds 1, there exists a unique infected steady state which is globally asymptotically stable. The model can be extended to study virus dynamics with multiple compartments or coinfection by multiple types of viruses. We also show that under some scenarios the age-structured model can be reduced to an ordinary differential equation system with or without time delays.

Citation: Shaoli Wang, Jianhong Wu, Libin Rong. A note on the global properties of an age-structured viral dynamic model with multiple target cell populations. Mathematical Biosciences & Engineering, 2017, 14 (3) : 805-820. doi: 10.3934/mbe.2017044
##### References:

show all references

##### References:
 [1] Sergio Grillo, Jerrold E. Marsden, Sujit Nair. Lyapunov constraints and global asymptotic stabilization. Journal of Geometric Mechanics, 2011, 3 (2) : 145-196. doi: 10.3934/jgm.2011.3.145 [2] C. Connell McCluskey. Global stability for an $SEI$ model of infectious disease with age structure and immigration of infecteds. Mathematical Biosciences & Engineering, 2016, 13 (2) : 381-400. doi: 10.3934/mbe.2015008 [3] Peter Giesl. Construction of a global Lyapunov function using radial basis functions with a single operator. Discrete & Continuous Dynamical Systems - B, 2007, 7 (1) : 101-124. doi: 10.3934/dcdsb.2007.7.101 [4] Andrei Korobeinikov, Philip K. Maini. A Lyapunov function and global properties for SIR and SEIR epidemiological models with nonlinear incidence. Mathematical Biosciences & Engineering, 2004, 1 (1) : 57-60. doi: 10.3934/mbe.2004.1.57 [5] J. W. Neuberger. How to distinguish a local semigroup from a global semigroup. Discrete & Continuous Dynamical Systems, 2013, 33 (11&12) : 5293-5303. doi: 10.3934/dcds.2013.33.5293 [6] Andrey V. Melnik, Andrei Korobeinikov. Lyapunov functions and global stability for SIR and SEIR models with age-dependent susceptibility. Mathematical Biosciences & Engineering, 2013, 10 (2) : 369-378. doi: 10.3934/mbe.2013.10.369 [7] Yu Yang, Shigui Ruan, Dongmei Xiao. Global stability of an age-structured virus dynamics model with Beddington-DeAngelis infection function. Mathematical Biosciences & Engineering, 2015, 12 (4) : 859-877. doi: 10.3934/mbe.2015.12.859 [8] C. Connell McCluskey. Global stability for an SEI epidemiological model with continuous age-structure in the exposed and infectious classes. Mathematical Biosciences & Engineering, 2012, 9 (4) : 819-841. doi: 10.3934/mbe.2012.9.819 [9] Andrey V. Melnik, Andrei Korobeinikov. Global asymptotic properties of staged models with multiple progression pathways for infectious diseases. Mathematical Biosciences & Engineering, 2011, 8 (4) : 1019-1034. doi: 10.3934/mbe.2011.8.1019 [10] Yu Yang, Yueping Dong, Yasuhiro Takeuchi. Global dynamics of a latent HIV infection model with general incidence function and multiple delays. Discrete & Continuous Dynamical Systems - B, 2019, 24 (2) : 783-800. doi: 10.3934/dcdsb.2018207 [11] Jacek Banasiak, Eddy Kimba Phongi, MirosŁaw Lachowicz. A singularly perturbed SIS model with age structure. Mathematical Biosciences & Engineering, 2013, 10 (3) : 499-521. doi: 10.3934/mbe.2013.10.499 [12] Fengqi Yi, Hua Zhang, Alhaji Cherif, Wenying Zhang. Spatiotemporal patterns of a homogeneous diffusive system modeling hair growth: Global asymptotic behavior and multiple bifurcation analysis. Communications on Pure & Applied Analysis, 2014, 13 (1) : 347-369. doi: 10.3934/cpaa.2014.13.347 [13] Jóhann Björnsson, Peter Giesl, Sigurdur F. Hafstein, Christopher M. Kellett. Computation of Lyapunov functions for systems with multiple local attractors. Discrete & Continuous Dynamical Systems, 2015, 35 (9) : 4019-4039. doi: 10.3934/dcds.2015.35.4019 [14] Xueting Tian, Shirou Wang, Xiaodong Wang. Intermediate Lyapunov exponents for systems with periodic orbit gluing property. Discrete & Continuous Dynamical Systems, 2019, 39 (2) : 1019-1032. doi: 10.3934/dcds.2019042 [15] Yi Yang, Robert J. Sacker. Periodic unimodal Allee maps, the semigroup property and the $\lambda$-Ricker map with Allee effect. Discrete & Continuous Dynamical Systems - B, 2014, 19 (2) : 589-606. doi: 10.3934/dcdsb.2014.19.589 [16] Sophia R.-J. Jang. Discrete host-parasitoid models with Allee effects and age structure in the host. Mathematical Biosciences & Engineering, 2010, 7 (1) : 67-81. doi: 10.3934/mbe.2010.7.67 [17] Suxia Zhang, Xiaxia Xu. A mathematical model for hepatitis B with infection-age structure. Discrete & Continuous Dynamical Systems - B, 2016, 21 (4) : 1329-1346. doi: 10.3934/dcdsb.2016.21.1329 [18] Toshikazu Kuniya, Jinliang Wang, Hisashi Inaba. A multi-group SIR epidemic model with age structure. Discrete & Continuous Dynamical Systems - B, 2016, 21 (10) : 3515-3550. doi: 10.3934/dcdsb.2016109 [19] Bin-Guo Wang, Wan-Tong Li, Liang Zhang. An almost periodic epidemic model with age structure in a patchy environment. Discrete & Continuous Dynamical Systems - B, 2016, 21 (1) : 291-311. doi: 10.3934/dcdsb.2016.21.291 [20] Yueding Yuan, Zhiming Guo, Moxun Tang. A nonlocal diffusion population model with age structure and Dirichlet boundary condition. Communications on Pure & Applied Analysis, 2015, 14 (5) : 2095-2115. doi: 10.3934/cpaa.2015.14.2095

2018 Impact Factor: 1.313