Equilibria and stability analysis of a branched metabolic network with feedback inhibition

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March 2006, 1(1): 219-239. doi: 10.3934/nhm.2006.1.219

Equilibria and stability analysis of a branched metabolic network with feedback inhibition

Yacine Chitour ^1, , Frédéric Grognard ^2, and Georges Bastin ^3,

1.	Laboratoire des systèmes et signaux, Université Paris-Sud, CNRS, Supélec, 91192, Gif-sur-Yvette
2.	INRIA Sophia-Antipolis, COMORE Project-team, 2004 route des lucioles, BP 93, 06902 Sophia-Antipolis Cedex, France
3.	Centre for Systems Engineering and Applied Mechanics (CESAME), Université Catholique de Louvain, Bâtiment Euler, 4-6, avenue G.Lemaitre,, 1348 Louvain la Neuve, Belgium

Received June 2005 Revised September 2005 Published January 2006

Abstract
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This paper deals with the analysis of a metabolic network with feedback inhibition. The considered system is an acyclic network of mono-molecular enzymatic reactions in which metabolites can act as feedback regulators on enzymes located "at the beginning" of their own pathway, and in which one metabolite is the root of the whole network. We show, under mild assumptions, the uniqueness of the equilibrium. We then show that this equilibrium is globally attractive if we impose conditions on the kinetic parameters of the metabolic reactions. Finally, when these conditions are not satisfied, we show, with a specific fourth-order example, that the equilibrium may become unstable with an attracting limit cycle.

Keywords: small-gain., equilibria, stability, Metabolic networks.

Mathematics Subject Classification: 93B05, 93B60, 35P2.

Citation: Yacine Chitour, Frédéric Grognard, Georges Bastin. Equilibria and stability analysis of a branched metabolic network with feedback inhibition. Networks & Heterogeneous Media, 2006, 1 (1) : 219-239. doi: 10.3934/nhm.2006.1.219

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