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Do longer delays matter? The effect of prolonging delay in CTL activation

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  • The activation of a speci c immune response takes place in the lymphoid organs such as the spleen. We present here a simpli ed model of the proliferation of speci c immune cells in the form of a single delay equation. We show that the system can undergo switches in stability as the delay is increased, and we interpret these results in the context of sustaining an e ective immune response to a dendritic cell vaccine.
    Mathematics Subject Classification: Primary: 34K60, 37N25; Secondary: 92B05.

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