American Institute of Mathematical Sciences

We recently derived a method, local orthogonal rectification (LOR), that provides a natural and useful geometric frame for analyzing dynamics relative to a base curve in the phase plane for two-dimensional systems of ODEs (Letson and Rubin, SIAM J. Appl. Dyn. Syst., 2018). This work extends LOR to apply to any embedded base manifold in a system of ODEs of arbitrary dimension and establishes a corresponding system of LOR equations for analyzing dynamics within the LOR frame, which maps naturally back to the original phase space. The LOR equations encode geometric properties of the underlying flow and remain valid, in general, beyond a local neighborhood of the embedded manifold. In addition to developing a general theory for LOR that makes use of a given normal frame, we show how to construct a normal frame that conveniently simplifies the computations involved in LOR. Finally, we illustrate the utility of LOR by showing that a blow-up transformation on the LOR equations provides a useful decomposition for studying trajectories' behavior relative to the embedded base manifold and by using LOR to identify canard behavior near a fold of a critical manifold in a two-timescale system.

We give answer to an open question by proving a sufficient optimality condition for state-linear optimal control problems with time delays in state and control variables. In the proof of our main result, we transform a delayed state-linear optimal control problem to an equivalent non-delayed problem. This allows us to use a well-known theorem that ensures a sufficient optimality condition for non-delayed state-linear optimal control problems. An example is given in order to illustrate the obtained result.

We consider a generational and continuous-time two-phase model of the cell cycle. The first model is given by a stochastic operator, and the second by a piecewise deterministic Markov process. In the second case we also introduce a stochastic semigroup which describes the evolution of densities of the process. We study long-time behaviour of these models. In particular we prove theorems on asymptotic stability and sweeping. We also show the relations between both models.

Tuberculosis (TB) is a leading cause of death from infectious disease. TB is caused mainly by a bacterium called Mycobacterium tuberculosis which often initiates in the respiratory tract. The interaction of macrophages and T cells plays an important role in the immune response during TB infection. Recent experimental results support that active TB infection may be induced by the dysfunction of Treg cell regulation that provides a balance between anti-TB T cell responses and pathology. To better understand the dynamics of TB infection and Treg cell regulation, we build a mathematical model using a system of differential equations that qualitatively and quantitatively characterizes the dynamics of macrophages, Th1 and Treg cells during TB infection. For sufficiently analyzing the interaction between immune response and bacterial infection, we separate our model into several simple subsystems for further steady state and stability studies. Using this system, we explore the conditions of parameters for three situations, recovery, latent disease and active disease, during TB infection. Our numerical simulations support that Th1 cells and Treg cells play critical roles in TB infection: Th1 cells inhibit the number of infected macrophages to reduce the chance of active disease; Treg cell regulation reduces the immune response to stabilize the dynamics of the system.

We consider a model of phenotypic evolution in populations with assortative mating of individuals. The model is given by a nonlinear operator acting on the space of probability measures and describes the relation between parental and offspring trait distributions. We study long-time behavior of trait distribution and show that it converges to a combination of Dirac measures. This result means that assortative mating can lead to a polymorphic population and sympatric speciation.

A new theorem on asymptotic stability of stochastic semigroups is given. This theorem is applied to a stochastic semigroup corresponding to Stein's neuronal model. Asymptotic properties of models with and without the refractory period are compared.

The control of complex nonlinear dynamical networks is an ongoing challenge in diverse contexts ranging from biology to social sciences. To explore a practical framework for controlling nonlinear dynamical networks based on meaningful physical and experimental considerations, we propose a new concept of the domain control for nonlinear dynamical networks, i.e., the control of a nonlinear network in transition from the domain of attraction of an undesired state (attractor) to the domain of attraction of a desired state. We theoretically prove the existence of a domain control. In particular, we offer an approach for identifying the driver nodes that need to be controlled and design a general form of control functions for realizing domain controllability. In addition, we demonstrate the effectiveness of our theory and approaches in three realistic disease-related networks: the epithelial-mesenchymal transition (EMT) core network, the T helper (Th) differentiation cellular network and the cancer network. Moreover, we reveal certain genes that are critical to phenotype transitions of these systems. Therefore, the approach described here not only offers a practical control scheme for nonlinear dynamical networks but also helps the development of new strategies for the prevention and treatment of complex diseases.

A continuum model for a population of self-propelled particles interacting through nematic alignment is derived from an individual-based model. The methodology consists of introducing a hydrodynamic scaling of the corresponding mean field kinetic equation. The resulting perturbation problem is solved thanks to the concept of generalized collision invariants. It yields a hyperbolic but non-conservative system of equations for the nematic mean direction of the flow and the densities of particles flowing parallel or anti-parallel to this mean direction. Diffusive terms are introduced under a weakly non-local interaction assumption and the diffusion coefficient is proven to be positive. An application to the modeling of myxobacteria is outlined.